There’s some discussion in 2.20 Go Fish that Angel can’t drink the blood of the swim team as it’s contaminated. This is first shown in 2.03 School Hard when Spike talks about being at Woodstock and drinking from a drugged hippy there.
Related episodes: 2.03 School Hard, 2.20 Go Fish
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HarFang on April 17th, 2008 at 7:56 pm
There is another reference to drugged blood in Angel (episode Orpheus), where that trick is used to capture him.